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Nitric oxide and carbon monoxide antagonize TGF-β through ligand-independent internalization of TβR1/ALK5

Transforming growth factor (TGF)-β plays a central role in vascular homeostasis and in the pathology of vascular disease. There is a growing appreciation for the role of nitric oxide (NO) and carbon monoxide (CO) as highly diffusible, bioactive signaling molecules in the vasculature. We hypothesized...

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Detalhes bibliográficos
Main Authors: Hovater, Michael B., Ying, Wei-Zhong, Agarwal, Anupam, Sanders, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166728/
https://ncbi.nlm.nih.gov/pubmed/25100282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00353.2014
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