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Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases

TAL-effector nucleases (TALENs) are attractive tools for sequence-specific genome modifications, but their delivery still remains problematic. It is well known that the presence of multiple sequence repeats in TALEN genes hampers the use of lentiviral vectors. We report that lentiviral vectors readi...

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Detalhes bibliográficos
Main Authors: Mock, Ulrike, Riecken, Kristoffer, Berdien, Belinda, Qasim, Waseem, Chan, Emma, Cathomen, Toni, Fehse, Boris
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166709/
https://ncbi.nlm.nih.gov/pubmed/25230987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06409
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