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Distinct ET(A) Receptor Binding Mode of Macitentan As Determined by Site Directed Mutagenesis
The competitive endothelin receptor antagonists (ERA) bosentan and ambrisentan, which have long been approved for the treatment of pulmonary arterial hypertension, are characterized by very short (1 min) occupancy half-lives at the ET(A) receptor. The novel ERA macitentan, displays a 20-fold increas...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4166607/ https://ncbi.nlm.nih.gov/pubmed/25226600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107809 |
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