The KDM2B- Let-7b -EZH2 Axis in Myelodysplastic Syndromes as a Target for Combined Epigenetic Therapy

Both DNA and histone methylation are dysregulated in the myelodysplastic syndromes (MDS). Based on preliminary data we hypothesized that dysregulated interactions of KDM2B, let-7b and EZH2 signals lead to an aberrant epigenetic landscape. Gene expression in CD34+ cells from MDS marrows was analyzed...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Karoopongse, Ekapun, Yeung, Cecilia, Byon, John, Ramakrishnan, Aravind, Holman, Zaneta J., Jiang, Peter Y. Z., Yu, Qiang, Deeg, H. Joachim, Marcondes, A. Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166605/
https://ncbi.nlm.nih.gov/pubmed/25225797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107817
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky