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Intrapolypeptide Interactions between the GTPase Effector Domain (GED) and the GTPase Domain Form the Bundle Signaling Element in Dynamin Dimers

[Image: see text] Biochemical and structural studies of dynamin have shown that the C-terminus of the GTPase effector domain (GED) folds back and docks onto a platform created by the N- and C-terminal α-helices of the GTPase domain to form a three-helix bundle. While cross-linking studies suggested...

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Autors principals: Srinivasan, Saipraveen, Mattila, Juha-Pekka, Schmid, Sandra L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166026/
https://ncbi.nlm.nih.gov/pubmed/25171143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500998s
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