Downregulation of stargazin inhibits the enhanced surface delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluR1 subunit in rat dorsal horn and ameliorates postoperative pain

BACKGROUND: Stargazin is the first transmembrane protein known to regulate synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Yet, it is unclear whether regulation of the surface delivery of spinal AMPA receptor subunits by stargazin contributes to postoperativ...

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Main Authors: Guo, Ruijuan, Zhao, Yujie, Zhang, Meijuan, Wang, Yue, Shi, Rong, Liu, Yang, Xu, Jie, Wu, Anshi, Yue, Yun, Wu, Jing, Guan, Yun, Wang, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165695/
https://ncbi.nlm.nih.gov/pubmed/25093662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000291
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