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CB(1) Cannabinoid Receptors Promote Maximal FAK Catalytic Activity By Stimulating Cooperative Signaling Between Receptor Tyrosine Kinases and Integrins in Neuronal Cells
Tyrosine phosphorylation (Tyr-P) of focal adhesion kinase (FAK) regulates FAK activation. Phosphorylated FAK Tyr 397 binds Src family kinases (Src), which in turn directly phosphorylate FAK Tyr 576/577 to produce maximal FAK enzymatic activity. CB(1) cannabinoid receptors (CB(1)) are abundantly expr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4165595/ https://ncbi.nlm.nih.gov/pubmed/23571270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.03.020 |
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