Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease

Intraneuronal accumulation of amyloid β (iAβ) has been linked to mild cognitive impairment that may precede Alzheimer's disease (AD) onset. This neuropathological trait was recently mimicked in a novel animal model of AD, the hemizygous transgenic McGill-R-Thy1-APP (Tg(+/−)) rat. The characteri...

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Main Authors: Galeano, Pablo, Martino Adami, Pamela V., Do Carmo, Sonia, Blanco, Eduardo, Rotondaro, Cecilia, Capani, Francisco, Castaño, Eduardo M., Cuello, A. Claudio, Morelli, Laura
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165352/
https://ncbi.nlm.nih.gov/pubmed/25278855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2014.00321
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