Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease

Synaptic bioenergetic deficiencies may be associated with early Alzheimer's disease (AD). To explore this concept, we assessed pre-synaptic mitochondrial function in hemizygous (+/−)TgMcGill-R-Thy1-APP rats. The low burden of Aβ and the wide array of behavioral and cognitive impairments describ...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Martino Adami, Pamela V, Quijano, Celia, Magnani, Natalia, Galeano, Pablo, Evelson, Pablo, Cassina, Adriana, Do Carmo, Sonia, Leal, María C, Castaño, Eduardo M, Cuello, A Claudio, Morelli, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363729/
https://ncbi.nlm.nih.gov/pubmed/26661224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15615132
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