Common Structure of Rare Replication-Deficient E1-Positive Particles in Adenoviral Vector Batches

The use of the PER.C6 adenovirus packaging cell line in combination with a designated vector plasmid system, whereby the cell line and vector with E1 deleted have no sequence overlap, eliminates the generation of replication-competent adenovirus during vector production. However, we have found cytop...

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Dettagli Bibliografici
Autori principali: Murakami, Pete, Havenga, Menzo, Fawaz, Farah, Vogels, Ronald, Marzio, Giuseppe, Pungor, Erno, Files, Jim, Do, Linh, Goudsmit, Jaap, McCaman, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC416523/
https://ncbi.nlm.nih.gov/pubmed/15163713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6200-6208.2004
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