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Fluoxetine Blocks Na(v)1.5 Channels via a Mechanism Similar to That of Class 1 Antiarrhythmics
The voltage-gated Na(v)1.5 channel is essential for the propagation of action potentials in the heart. Malfunctions of this channel are known to cause hereditary diseases. It is a prime target for class 1 antiarrhythmic drugs and a number of antidepressants. Our study investigated the Na(v)1.5 block...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4164981/ https://ncbi.nlm.nih.gov/pubmed/25028482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.093104 |
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