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An Automated Process for a Sequential Heterocycle/Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-(Thiazol-2-yl)-3,4-Dihydropyrimidin-2(1H)-ones

The first example of a sequential heterocycle formation/multicomponent reaction using an automated continuous flow microreactor assembly is reported. Consecutive Hantzsch thiazole synthesis, deketalization, and Biginelli multicomponent reaction provides rapid and efficient access to highly functiona...

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Détails bibliographiques
Auteurs principaux: Pagano, Nicholas, Herath, Ananda, Cosford, Nicholas D. P.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164902/
https://ncbi.nlm.nih.gov/pubmed/25237558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1556/jfchem.2011.00001
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