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Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives

The multistep continuous flow assembly of 2-(1H-indol-3-yl)thiazoles using a Syrris AFRICA(®) synthesis station is reported. Sequential Hantzsch thiazole synthesis, deketalization and Fischer indole synthesis provides rapid and efficient access to highly functionalized, pharmacologically significant...

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Hlavní autoři: Pagano, Nicholas, Heil, Marintha L., Cosford, Nicholas D. P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953499/
https://ncbi.nlm.nih.gov/pubmed/24634547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0031-1290953
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