Double Transgenic Pigs with Combined Expression of Human α1,2-Fucosyltransferase and α-Galactosidase Designed to Avoid Hyperacute Xenograft Rejection

Hyperacute rejection (HAR) depends on the response of xenoreactive antibodies principally against porcine α-Gal epitope. Methods eliminating HAR include GGTA1 inactivation, regulation of the complement system and modification of the oligosaccharide structure of surface proteins in donor’s cells. Tra...

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Autori principali: Zeyland, Joanna, Woźniak, Anna, Gawrońska, Barbara, Juzwa, Wojciech, Jura, Jacek, Nowak, Agnieszka, Słomski, Ryszard, Smorąg, Zdzisław, Szalata, Marlena, Mazurek, Urszula, Lipiński, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Basel 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164832/
https://ncbi.nlm.nih.gov/pubmed/24554032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00005-014-0280-3
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