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4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation
eIF4E-binding proteins (4E-BPs) are a widespread class of translational regulators that share a canonical (C) eIF4E-binding motif (4E-BM) with eIF4G. Consequently, 4E-BPs compete with eIF4G for binding to the dorsal surface on eIF4E to inhibit translation initiation. Some 4E-BPs contain non-canonica...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Pub. Group
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4164784/ https://ncbi.nlm.nih.gov/pubmed/25179781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5790 |
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