A multi-institutional study of the prevalence of BRCA1 and BRCA2 large genomic rearrangements in familial breast cancer patients

BACKGROUND: Large genomic rearrangements (LGRs) in the BRCA1/2 genes are frequently observed in breast cancer patients who are negative for BRCA1/2 small mutations. Here, we examined 221 familial breast cancer patients from 37 hospitals to estimate the contribution of LGRs, in a nationwide context,...

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Hlavní autoři: Seong, Moon-Woo, Cho, Sung Im, Kim, Kyu Hyung, Chung, Il Yong, Kang, Eunyoung, Lee, Jong Won, Park, Sue K, Lee, Min Hyuk, Choi, Doo Ho, Yom, Cha Kyong, Noh, Woo-Chul, Chang, Myung Chul, Park, Sung Sup, Kim, Sung-Won
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164743/
https://ncbi.nlm.nih.gov/pubmed/25176351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-645
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