Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b(+ )myelopoiesis

Collagen-induced arthritis (CIA) in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b(+ )myeloblasts. Both disease manifestations are more pronounced in interferon-γ receptor knock-out (IFN-γR KO) mice. We have taken advantage of this difference to test the hypothe...

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Main Authors: De Klerck, Bert, Carpentier, Isabelle, Lories, Rik J, Habraken, Yvette, Piette, Jacques, Carmeliet, Geert, Beyaert, Rudi, Billiau, Alfons, Matthys, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC416444/
https://ncbi.nlm.nih.gov/pubmed/15142268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1167
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