The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells

Abstract CD8+ T cells play an important role in anti-tumor immunity. Better understanding of their regulation could advance cancer immunotherapies. Here we identify, via stepwise CRISPR-based screening, that CUL5 is a negative regulator of the core signaling pathways of CD8+ T cells. Knocking out CU...

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ग्रंथसूची विवरण

मुख्य लेखकों:	Xiaofeng Liao, Wenxue Li, Hongyue Zhou, Barani Kumar Rajendran, Ao Li, Jingjing Ren, Yi Luan, David A. Calderwood, Benjamin Turk, Wenwen Tang, Yansheng Liu, Dianqing Wu
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Nature Portfolio 2024-01-01
श्रृंखला:	Nature Communications
ऑनलाइन पहुंच:	https://doi.org/10.1038/s41467-024-44885-0
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