Promoter-Dependent Mechanism Leading to Selective Hypomethylation within the 5′ Region of Gene MAGE-A1 in Tumor Cells

Several male germ line-specific genes, including MAGE-A1, rely on DNA methylation for their repression in normal somatic tissues. These genes become activated in many types of tumors in the course of the genome-wide demethylation process which often accompanies tumorigenesis. We show that in tumor c...

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שמור ב:
מידע ביבליוגרפי
Main Authors: De Smet, Charles, Loriot, Axelle, Boon, Thierry
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2004
נושאים:
Gene Expression
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC416434/
https://ncbi.nlm.nih.gov/pubmed/15143172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.4781-4790.2004
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