Role of CTCF Binding Sites in the Igf2/H19 Imprinting Control Region

A ∼2.4-kb imprinting control region (ICR) regulates somatic monoallelic expression of the Igf2 and H19 genes. This is achieved through DNA methylation-dependent chromatin insulator and promoter silencing activities on the maternal and paternal chromosomes, respectively. In somatic cells, the hypomet...

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Hlavní autoři: Szabó, Piroska E., Tang, Shih-Huey E., Silva, Francisco J., Tsark, Walter M. K., Mann, Jeffrey R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Transcriptional Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC416431/
https://ncbi.nlm.nih.gov/pubmed/15143173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.4791-4800.2004
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