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Role of CTCF Binding Sites in the Igf2/H19 Imprinting Control Region
A ∼2.4-kb imprinting control region (ICR) regulates somatic monoallelic expression of the Igf2 and H19 genes. This is achieved through DNA methylation-dependent chromatin insulator and promoter silencing activities on the maternal and paternal chromosomes, respectively. In somatic cells, the hypomet...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC416431/ https://ncbi.nlm.nih.gov/pubmed/15143173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.4791-4800.2004 |
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