A Direct Binding Site for Grb2 Contributes to Transformation and Leukemogenesis by the Tel-Abl (ETV6-Abl) Tyrosine Kinase

A direct binding site for the Grb2 adapter protein is required for the induction of fatal chronic myeloid leukemia (CML)-like disease in mice by Bcr-Abl. Here, we demonstrate direct binding of Grb2 to the Tel-Abl (ETV6-Abl) fusion protein, the product of complex (9;12) chromosomal translocations in...

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Bibliographische Detailangaben
Hauptverfasser: Million, Ryan P., Harakawa, Nari, Roumiantsev, Sergei, Varticovski, Lyuba, Van Etten, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC416425/
https://ncbi.nlm.nih.gov/pubmed/15143164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.4685-4695.2004
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