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Distinct Domains of AU-Rich Elements Exert Different Functions in mRNA Destabilization and Stabilization by p38 Mitogen-Activated Protein Kinase or HuR

AU-rich elements (AREs) control the expression of numerous genes by accelerating the decay of their mRNAs. Rapid decay and deadenylation of β-globin mRNA containing AU-rich 3′ untranslated regions of the chemoattractant cytokine interleukin-8 (IL-8) are strongly attenuated by activating the p38 mito...

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Published in:Mol Cell Biol
Main Authors: Winzen, Reinhard, Gowrishankar, Gayatri, Bollig, Frank, Redich, Natalie, Resch, Klaus, Holtmann, Helmut
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2004
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC416423/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15143177/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.11.4835-4847.2004
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