Sustained active site rigidity during synthesis by human DNA polymerase μ

DNA polymerase mu (Pol μ) is the only template-dependent human DNA polymerase capable of repairing double strand DNA breaks (DSBs) with unpaired 3′-ends in non-homologous end joining (NHEJ). To probe this function, we structurally characterized Pol μ’s catalytic cycle for single nucleotide incorpora...

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Main Authors: Moon, Andrea F., Pryor, John M., Ramsden, Dale A., Kunkel, Thomas A., Bebenek, Katarzyna, Pedersen, Lars C.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164209/
https://ncbi.nlm.nih.gov/pubmed/24487959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2766
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