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Sustained active site rigidity during synthesis by human DNA polymerase μ
DNA polymerase mu (Pol μ) is the only template-dependent human DNA polymerase capable of repairing double strand DNA breaks (DSBs) with unpaired 3′-ends in non-homologous end joining (NHEJ). To probe this function, we structurally characterized Pol μ’s catalytic cycle for single nucleotide incorpora...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4164209/ https://ncbi.nlm.nih.gov/pubmed/24487959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2766 |
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