Overexpression of the ped/pea-15 Gene Causes Diabetes by Impairing Glucose-Stimulated Insulin Secretion in Addition to Insulin Action

Overexpression of the ped/pea-15 gene is a common feature of type 2 diabetes. In the present work, we show that transgenic mice ubiquitously overexpressing ped/pea-15 exhibited mildly elevated random-fed blood glucose levels and decreased glucose tolerance. Treatment with a 60% fat diet led ped/pea-...

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Autori principali: Vigliotta, Giovanni, Miele, Claudia, Santopietro, Stefania, Portella, Giuseppe, Perfetti, Anna, Maitan, Maria Alessandra, Cassese, Angela, Oriente, Francesco, Trencia, Alessandra, Fiory, Francesca, Romano, Chiara, Tiveron, Cecilia, Tatangelo, Laura, Troncone, Giancarlo, Formisano, Pietro, Beguinot, Francesco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC416420/
https://ncbi.nlm.nih.gov/pubmed/15143191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.5005-5015.2004
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