Expression of a Dominant Negative Estrogen Receptor Alpha Variant in Transgenic Mice Accelerates Uterine Cancer Induced by the Potent Estrogen Diethylstilbestrol

ERΔ3 transgenic mice expressing a dominant negative estrogen receptor α (ERα) variant lacking the second zinc finger in the DNA binding domain were developed to examine its potential to inhibit estrogen action in vivo. To investigate if ERΔ3 expression influences uterine carcinogenesis, ERΔ3 transge...

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Hlavní autoři: Davis, Vicki L., Newbold, Retha R., Couse, John F., Rea, Sheri L., Gallagher, Katie M., Hamilton, Katherine J., Goulding, Eugenia H., Jefferson, Wendy, Eddy, E. M., Bullock, Bill C., Korach, Kenneth S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164054/
https://ncbi.nlm.nih.gov/pubmed/22989549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2012.08.005
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