Developmental Exposure to Diethylstilbestrol Alters Uterine Gene Expression That May Be Associated With Uterine Neoplasia Later in Life

Previously, we described a mouse model where the well-known reproductive carcinogen with estrogenic activity, diethylstilbestrol (DES), caused uterine adenocarcinoma following neonatal treatment. Tumor incidence was dose-dependent reaching >90% by 18 mo following neonatal treatment with 1000 μg/k...

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Hlavní autoři: Newbold, Retha R., Jefferson, Wendy N., Grissom, Sherry F., Padilla-Banks, Elizabeth, Snyder, Ryan J., Lobenhofer, Edward K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254327/
https://ncbi.nlm.nih.gov/pubmed/17394237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20308
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