BIIL 284 reduces neutrophils numbers but increases P. aeruginosa bacteraemia and inflammation in mouse lungs

BACKGROUND: A clinical study to investigate the leukotriene B(4) (LTB(4))-receptor antagonist BIIL 284 in cystic fibrosis (CF) patients was prematurely terminated due to a significantly increased risk of adverse pulmonary events. We aimed to establish the effect of BIIL284 in models of Pseudomonas a...

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Main Authors: Döring, Gerd, Bragonzi, Alessandra, Paroni, Moira, Aktürk, Firdevs-Fatma, Cigana, Cristina, Schmidt, Annika, Gilpin, Deirdre, Heyder, Susanne, Born, Torsten, Smaczny, Christina, Kohlhäufl, Martin, Wagner, Thomas O. F., Loebinger, Michael R., Bilton, Diana, Tunney, Michael M., Elborn, J. Stuart, Pier, Gerald B., Konstan, Michael W., Ulrich, Martina
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163938/
https://ncbi.nlm.nih.gov/pubmed/24183915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2013.10.007
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