Fosfomycin and Tobramycin in Combination Downregulate Nitrate Reductase Genes narG and narH, Resulting in Increased Activity against Pseudomonas aeruginosa under Anaerobic Conditions

The activity of aminoglycosides, which are used to treat Pseudomonas aeruginosa respiratory infection in cystic fibrosis (CF) patients, is reduced under the anaerobic conditions that reflect the CF lung in vivo. In contrast, a 4:1 (wt/wt) combination of fosfomycin and tobramycin (F:T), which is unde...

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Detaylı Bibliyografya
Asıl Yazarlar: McCaughey, Gerard, Gilpin, Deirdre F., Schneiders, Thamarai, Hoffman, Lucas R., McKevitt, Matt, Elborn, J. Stuart, Tunney, Michael M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
Konular:
Susceptibility
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811241/
https://ncbi.nlm.nih.gov/pubmed/23959314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00750-13
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