Fosfomycin and Tobramycin in Combination Downregulate Nitrate Reductase Genes narG and narH, Resulting in Increased Activity against Pseudomonas aeruginosa under Anaerobic Conditions

The activity of aminoglycosides, which are used to treat Pseudomonas aeruginosa respiratory infection in cystic fibrosis (CF) patients, is reduced under the anaerobic conditions that reflect the CF lung in vivo. In contrast, a 4:1 (wt/wt) combination of fosfomycin and tobramycin (F:T), which is unde...

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Detalhes bibliográficos
Main Authors: McCaughey, Gerard, Gilpin, Deirdre F., Schneiders, Thamarai, Hoffman, Lucas R., McKevitt, Matt, Elborn, J. Stuart, Tunney, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811241/
https://ncbi.nlm.nih.gov/pubmed/23959314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00750-13
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