Fosfomycin and Tobramycin in Combination Downregulate Nitrate Reductase Genes narG and narH, Resulting in Increased Activity against Pseudomonas aeruginosa under Anaerobic Conditions

The activity of aminoglycosides, which are used to treat Pseudomonas aeruginosa respiratory infection in cystic fibrosis (CF) patients, is reduced under the anaerobic conditions that reflect the CF lung in vivo. In contrast, a 4:1 (wt/wt) combination of fosfomycin and tobramycin (F:T), which is unde...

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Main Authors: McCaughey, Gerard, Gilpin, Deirdre F., Schneiders, Thamarai, Hoffman, Lucas R., McKevitt, Matt, Elborn, J. Stuart, Tunney, Michael M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Susceptibility
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811241/
https://ncbi.nlm.nih.gov/pubmed/23959314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00750-13
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