Establishment and characterization of bortezomib-resistant U266 cell line: Constitutive activation of NF-κB-mediated cell signals and/or alterations of ubiquitylation-related genes reduce bortezomib-induced apoptosis

Bortezomib has been known as the most promising anti-cancer drug for multiple myeloma (MM). However, recent studies reported that not all MM patients respond to bortezomib. To overcome such a stumbling-block, studies are needed to clarify the mechanisms of bortezomib resistance. In this study, we es...

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Main Authors: Park, Juwon, Bae, Eun-Kyung, Lee, Chansu, Choi, Jee-Hye, Jung, Woo June, Ahn, Kwang-Sung, Yoon, Sung-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163865/
https://ncbi.nlm.nih.gov/pubmed/24286313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2014.47.5.134
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