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MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN

HER2-overexpressing breast cancers are characterized by frequent distant metastasis and often develop resistance after short-term effective treatment with the monoclonal antibody drug, trastuzumab. Here, we found that the oncogenic miRNA, miR-221, inhibited apoptosis, induced trastuzumab resistance...

詳細記述

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書誌詳細
主要な著者: Ye, Xingming, Bai, Wendong, Zhu, Huayu, Zhang, Xiao, Chen, Ying, Wang, Lei, Yang, Angang, Zhao, Jing, Jia, Lintao
フォーマット: Artigo
言語:Inglês
出版事項: Korean Society for Biochemistry and Molecular Biology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163864/
https://ncbi.nlm.nih.gov/pubmed/24286315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2014.47.5.165
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