Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R

BACKGROUND: Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor receptors, in particular, the insulin-like growth factor 1 receptor (IGF1R), re...

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Bibliographic Details
Main Authors: Ye, Xing-Ming, Zhu, Hua-Yu, Bai, Wen-Dong, Wang, Ting, Wang, Lei, Chen, Ying, Yang, An-Gang, Jia, Lin-Tao
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974046/
https://ncbi.nlm.nih.gov/pubmed/24571711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-134
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