TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan

BACKGROUND AND OBJECTIVE: Small cell lung cancer (SCLC) is one of the most challenging tumors to treat due to high proliferation rate, early metastatic dissemination and rapid development of chemotherapy resistance. The current treatment protocols involve the use of topoisomerase 1 (TOP1) poisons su...

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Bibliographic Details
Main Authors: Meisenberg, Cornelia, Ward, Simon E, Schmid, Peter, El-Khamisy, Sherif F
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163653/
https://ncbi.nlm.nih.gov/pubmed/25232464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/1948-5956.1000280
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