The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling.

Antigen-specific activation of T lymphocytes, via stimulation of the T-cell antigen receptor (TCR) complex, is marked by a rapid and sustained increase in the concentration of cytoplasmic free Ca2+ ([Ca2+]i). It has been suggested that the second messenger inositol 1,4,5-trisphosphate (IP3) produced...

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Bibliografiska uppgifter

I publikationen:	Proc Natl Acad Sci U S A
Huvudupphov:	Jayaraman, T, Ondriasová, E, Ondrias, K, Harnick, D J, Marks, A R
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	National Academy of Sciences 1995
Ämnen:	Research Article
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41631/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7597070/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.13.6007
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