RECIPIENT PRETRANSPLANT INOSINE MONOPHOSPHATE DEHYDROGENASE ACTIVITY IN NONMYELOABLATIVE HCT

Mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), inhibits inosine monophosphate dehydrogenase (IMPDH) activity. IMPDH is the rate-limiting enzyme involved in de novo synthesis of guanosine nucleotides and catalyzes the oxidation of inosine 5’- monophosphate (IMP) to xanthosin...

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Autors principals: Bemer, Meagan J., Risler, Linda J., Phillips, Brian R., Wang, Joanne, Storer, Barry E., Sandmaier, Brenda M., Duan, Haichuan, Raccor, Brianne S., Boeckh, Michael J., McCune, Jeannine S.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163086/
https://ncbi.nlm.nih.gov/pubmed/24923537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2014.05.032
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