Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity

Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are currently known for only ~1% of all eukaryotic TFs. Broadly sampling DNA-binding domain (DBD) types from multiple eukaryotic clades, we determined DNA sequence preferences for >1,000 TFs encompassing 54 d...

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Main Authors: Weirauch, Matthew T., Yang, Ally, Albu, Mihai, Cote, Atina, Montenegro-Montero, Alejandro, Drewe, Philipp, Najafabadi, Hamed S., Lambert, Samuel A., Mann, Ishminder, Cook, Kate, Zheng, Hong, Goity, Alejandra, van Bakel, Harm, Lozano, Jean-Claude, Galli, Mary, Lewsey, Mathew, Huang, Eryong, Mukherjee, Tuhin, Chen, Xiaoting, Reece-Hoyes, John S., Govindarajan, Sridhar, Shaulsky, Gad, Walhout, Albertha J.M., Bouget, François-Yves, Ratsch, Gunnar, Larrondo, Luis F., Ecker, Joseph R., Hughes, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163041/
https://ncbi.nlm.nih.gov/pubmed/25215497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.08.009
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