The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: Down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms

The tobacco-related species Nicotiana benthamiana has recently emerged as a promising host for the manufacturing of protein therapeutics. However, the production of recombinant proteins in N. benthamiana is frequently hampered by undesired proteolysis. Here, we show that the expression of the human...

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Bibliografski detalji
Glavni autori: Niemer, Melanie, Mehofer, Ulrich, Torres Acosta, Juan Antonio, Verdianz, Maria, Henkel, Theresa, Loos, Andreas, Strasser, Richard, Maresch, Daniel, Rademacher, Thomas, Steinkellner, Herta, Mach, Lukas
Format: Artigo
Jezik:Inglês
Izdano: WILEY-VCH Verlag 2014
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162989/
https://ncbi.nlm.nih.gov/pubmed/24478053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201300207
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