Locked Nucleic Acid and TaqMan Probes to Detect KRAS Mutations by Droplet Digital PCR in Colorectal Carcinoma Formalin Fixed Paraffin Embedded Tissue Samples

BACKGROUND: Metastatic colorectal carcinoma (CRC) tumors with KRAS mutations in exon 2, codons 12 and 13, do not benefit from anti-epidermal growth factor receptor (EGFR) antibody therapy. Current best practice recommends that KRAS mutation analysis be included in patients with CRC as a prerequisite...

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Main Authors: Chapman, B., Brown, A., Cooper, S., Yang, W., Karlin-Neumann, G., Binder, S., Sullivan, D.C.
Formato: Artigo
Idioma:Inglês
Publicado em: Association of Biomolecular Resource Facilities 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162247/
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