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Liver Clock Protein BMAL1 Promotes de Novo Lipogenesis through Insulin-mTORC2-AKT Signaling

The clock protein BMAL1 (brain and muscle Arnt-like protein 1) participates in circadian regulation of lipid metabolism, but its contribution to insulin AKT-regulated hepatic lipid synthesis is unclear. Here we used both Bmal1(−/−) and acute liver-specific Bmal1-depleted mice to study the role of BM...

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מידע ביבליוגרפי
Main Authors: Zhang, Deqiang, Tong, Xin, Arthurs, Blake, Guha, Anirvan, Rui, Liangyou, Kamath, Avani, Inoki, Ken, Yin, Lei
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162191/
https://ncbi.nlm.nih.gov/pubmed/25063808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.567628
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