The N- and C-terminal Domains of Tomosyn Play Distinct Roles in Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Binding and Fusion Regulation

Tomosyn negatively regulates SNARE-dependent exocytic pathways including insulin secretion, GLUT4 exocytosis, and neurotransmitter release. The molecular mechanism of tomosyn, however, has not been fully elucidated. Here, we reconstituted SNARE-dependent fusion reactions in vitro to recapitulate the...

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Main Authors: Yu, Haijia, Rathore, Shailendra S., Gulbranson, Daniel R., Shen, Jingshi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162162/
https://ncbi.nlm.nih.gov/pubmed/25063806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591487
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