Delta FosB and AP-1-mediated transcription modulate cannabinoid CB(1) receptor signaling and desensitization in striatal and limbic brain regions

Repeated Δ(9)-tetrahydrocannabinol (THC) administration produces cannabinoid type 1 receptor (CB(1)R) desensitization and downregulation, as well as tolerance to its in vivo pharmacological effects. However, the magnitude of CB(1)R desensitization varies by brain region, with CB(1)Rs in the striatum...

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Hauptverfasser: Lazenka, Matthew F., David, Bethany G., Lichtman, Aron H., Nestler, Eric J., Selley, Dana E., Sim-Selley, Laura J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162133/
https://ncbi.nlm.nih.gov/pubmed/25093286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.07.024
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