MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

Sirtuin 6 (SIRT6) is associated with longevity and is also a tumor suppressor. Identification of molecular regulators of SIRT6 might enable its activation therapeutically in cancer patients. In various breast cancer cell lines, we found that SIRT6 was phosphorylated at Ser(338) by the kinase AKT1, w...

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Detaylı Bibliyografya
Asıl Yazarlar: Thirumurthi, Umadevi, Shen, Jia, Xia, Weiya, LaBaff, Adam M., Wei, Yongkun, Li, Chia-Wei, Chang, Wei-Chao, Chen, Chung-Hsuan, Lin, Hui-Kuan, Yu, Dihua, Hung, Mien-Chie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161976/
https://ncbi.nlm.nih.gov/pubmed/25074979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005076
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