Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease

Amylin, a pancreatic peptide, and amyloid-beta peptides (Aβ), a major component of Alzheimer's disease (AD) brain, share similar β-sheet secondary structures, but it is not known whether pancreatic amylin affects amyloid pathogenesis in the AD brain. Using AD mouse models, we investigated the e...

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Detalhes bibliográficos
Main Authors: Zhu, H, Wang, X, Wallack, M, Li, H, Carreras, I, Dedeoglu, A, Hur, J-Y, Zheng, H, Fine, R, Mwamburi, M, Sun, X, Kowall, N, Stern, R A, Qiu, W Q
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161670/
https://ncbi.nlm.nih.gov/pubmed/24614496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2014.17
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