HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses

The catalytic site of the HIV integrase is contained within an RNase H-like fold, and numerous drugs have been developed that bind to this site and inhibit its activity. Herpes simplex virus (HSV) encodes two proteins with potential RNase H-like folds, the infected cell protein 8 (ICP8) DNA-binding...

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Библиографические подробности
Главные авторы: Yan, Zhipeng, Bryant, Kevin F., Gregory, Sean M., Angelova, Magdalena, Dreyfus, David H., Zhao, Xue Zhi, Coen, Donald M., Burke, Terrence R., Knipe, David M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Microbiology 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161245/
https://ncbi.nlm.nih.gov/pubmed/24987091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01318-14
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