Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes

There is increasing evidence that deficient clearance of β-amyloid (Aβ) contributes to its accumulation in late-onset Alzheimer disease (AD). Several Aβ-degrading enzymes, including neprilysin (NEP), endothelin-converting enzyme (ECE), and angiotensin-converting enzyme (ACE) reduce Aβ levels and pro...

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Detalhes bibliográficos
Main Authors: Miners, J. Scott, Palmer, Jennifer C., Tayler, Hannah, Palmer, Laura E., Ashby, Emma, Kehoe, Patrick G., Love, Seth
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160973/
https://ncbi.nlm.nih.gov/pubmed/25309424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00238
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