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Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor
[Image: see text] A new pseudopeptide epoxide inhibitor, designed for irreversible binding to HIV protease (HIV-PR), has been synthesized and characterized in solution and in the solid state. However, the crystal structure of the complex obtained by inhibitor–enzyme cocrystallization revealed that a...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2014
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160752/ https://ncbi.nlm.nih.gov/pubmed/25221650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500092e |
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