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Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor
[Image: see text] A new pseudopeptide epoxide inhibitor, designed for irreversible binding to HIV protease (HIV-PR), has been synthesized and characterized in solution and in the solid state. However, the crystal structure of the complex obtained by inhibitor–enzyme cocrystallization revealed that a...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , , , , , , |
|---|---|
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
American Chemical
Society
2014
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| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160752/ https://ncbi.nlm.nih.gov/pubmed/25221650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500092e |
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