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Acyclic Tethers Mimicking Subunits of Polysaccharide Ligands: Selectin Antagonists

[Image: see text] We report on the design and synthesis of molecules having E- and P-selectins blocking activity both in vitro and in vivo. The GlcNAc component of the selectin ligand sialyl Lewis(X) was replaced by an acyclic tether that links two saccharide units. The minimization of intramolecula...

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Detalhes bibliográficos
Main Authors: Calosso, Mickael, Tambutet, Guillaume, Charpentier, Daniel, St-Pierre, Gabrielle, Vaillancourt, Marc, Bencheqroun, Mohammed, Gratton, Jean-Philippe, Prévost, Michel, Guindon, Yvan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160748/
https://ncbi.nlm.nih.gov/pubmed/25221666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500266x
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