Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors

[Image: see text] Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure–activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.

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Autori principali: Subramanian, Sharadha, Costales, Abran, Williams, Teresa E., Levine, Barry, McBride, Christopher M., Poon, Daniel, Amiri, Payman, Renhowe, Paul A., Shafer, Cynthia M., Stuart, Darrin, Verhagen, Joelle, Ramurthy, Savithri
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160747/
https://ncbi.nlm.nih.gov/pubmed/25221654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002272
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