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Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue
The assessment of proarrhythmic risks of drugs remains challenging. To evaluate the suitability of rat engineered heart tissue (EHT) for detecting proarrhythmic effects. We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode)...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Springer Berlin Heidelberg
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160570/ https://ncbi.nlm.nih.gov/pubmed/25209140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-014-0436-7 |
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